Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2TLR4 Signaling Pathway
Joint Authors
Yang, Chun
Sun, Shengnan
Zhang, Qi
Guo, Jia
Wu, Tengfei
Liu, Ying
Yang, Min
Zhang, Yan
Peng, Yinghua
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-26
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Postoperative cognitive dysfunction (POCD) is a severe complication of cardiopulmonary bypass (CPB) and has common characteristics such as acute cognitive dysfunction, impaired memory, and inattention.
Mesenchymal stem cells (MSCs) are multipotent cells that have therapeutic potentials mainly through paracrine action via secreting growth factors and cytokines.
Exosomes are one of the important paracrine factors and have been reported as potential cell-free therapy for the treatment of autoimmune and central nervous system disorders.
In this study, we examined exosomes derived from antler MSCs (AMSCs) of POCD rats after CPB and evaluated their potential regulatory mechanisms.
AMSC-derived exosomes reduced neurological damage and brain damage and prevent apoptosis in CPB rats.
Furthermore, AMSC-derived exosomes were found to reduce hippocampal neuronal apoptosis and the expression of TLR2, TLR4, MyD88, and NF-κB in CPB rats.
However, the above effects of AMSC-derived exosomes on CPB rats were abolished partially by toll-like receptor 2/4 (TLR2/TLR4) agonist (LPS-EB).
In conclusion, AMSC-derived exosomes can improve cognitive function in CPB rats through inhibiting the TLR2/TLR4 signaling pathway.
American Psychological Association (APA)
Yang, Chun& Sun, Shengnan& Zhang, Qi& Guo, Jia& Wu, Tengfei& Liu, Ying…[et al.]. 2020. Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2TLR4 Signaling Pathway. Stem Cells International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207646
Modern Language Association (MLA)
Yang, Chun…[et al.]. Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2TLR4 Signaling Pathway. Stem Cells International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1207646
American Medical Association (AMA)
Yang, Chun& Sun, Shengnan& Zhang, Qi& Guo, Jia& Wu, Tengfei& Liu, Ying…[et al.]. Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2TLR4 Signaling Pathway. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207646