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TRAF6 Promotes Gastric Cancer Cell Self-Renewal, Proliferation, and Migration
Joint Authors
Zhang, Xiaobei
Yang, Mengting
Jin, Meng
Yang, Xiaxia
Gong, Aihua
Bie, Qingli
Li, Kailong
Zhang, Bin
Liu, Haifeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-17
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Gastric cancer is the third most common type of tumor associated with death.
TRAF6 belongs to the tumor necrosis factor receptor-associated factor family and has been demonstrated to be involved in tumor progression in various cancers.
However, the exact effect of TRAF6 on gastric cancer stem cells has not been extensively studied.
In this study, abnormal expression of TRAF6 was found in gastric cancer tissues.
Overexpression of TRAF6 enhanced proliferation and migration, and TRAF6 knockdown reversed this phenomenon in gastric cancer cells.
Moreover, TRAF6 may inhibit differentiation and promote stemness and epithelial-mesenchymal transition (EMT).
Transcriptome profiles revealed 701 differentially expressed genes in the wild-type group and the TRAF6 knockout group.
Potential molecules associated with cell proliferation and migration were identified, including MAPK, FOXO, and IL-17.
In conclusion, TRAF6 is a significant factor promoting proliferation and migration in gastric cancer cells and may provide a new target for the accurate treatment of gastric cancer.
American Psychological Association (APA)
Yang, Mengting& Jin, Meng& Li, Kailong& Liu, Haifeng& Yang, Xiaxia& Zhang, Xiaobei…[et al.]. 2020. TRAF6 Promotes Gastric Cancer Cell Self-Renewal, Proliferation, and Migration. Stem Cells International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1207701
Modern Language Association (MLA)
Yang, Mengting…[et al.]. TRAF6 Promotes Gastric Cancer Cell Self-Renewal, Proliferation, and Migration. Stem Cells International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1207701
American Medical Association (AMA)
Yang, Mengting& Jin, Meng& Li, Kailong& Liu, Haifeng& Yang, Xiaxia& Zhang, Xiaobei…[et al.]. TRAF6 Promotes Gastric Cancer Cell Self-Renewal, Proliferation, and Migration. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1207701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207701