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Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells
Joint Authors
Deschaseaux, Frédéric
Huynh, Anne
Bourin, Philippe
Espagnolle, Nicolas
Hebraud, Benjamin
Descamps, Jean-Gérard
Gadelorge, Mélanie
Joubert, Marie-Véronique
Ferreira, Laura Do Souto
Roussel, Murielle
Sensébé, Luc
Attal, Michel
Avet-Loiseau, Hervé
Corre, Jill
Casteilla, Louis
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-05
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Multiple myeloma (MM) is an incurable B cell neoplasia characterized by the accumulation of tumor plasma cells within the bone marrow (BM).
As a consequence, bone osteolytic lesions develop in 80% of patients and remain even after complete disease remission.
We and others had demonstrated that BM-derived mesenchymal stromal cells (MSCs) are abnormal in MM and thus cannot be used for autologous treatment to repair bone damage.
Adipose stromal cells (ASCs) represent an interesting alternative to MSCs for cellular therapy.
Thus, in this study, we wondered whether they could be a good candidate in repairing MM bone lesions.
For the first time, we present a transcriptomic, phenotypic, and functional comparison of ASCs from MM patients and healthy donors (HDs) relying on their autologous MSC counterparts.
In contrast to MM MSCs, MM ASCs did not exhibit major abnormalities.
However, the changes observed in MM ASCs and the supportive property of ASCs on MM cells question their putative and safety uses at an autologous or allogenic level.
American Psychological Association (APA)
Espagnolle, Nicolas& Hebraud, Benjamin& Descamps, Jean-Gérard& Gadelorge, Mélanie& Joubert, Marie-Véronique& Ferreira, Laura Do Souto…[et al.]. 2020. Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells. Stem Cells International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1207721
Modern Language Association (MLA)
Espagnolle, Nicolas…[et al.]. Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells. Stem Cells International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1207721
American Medical Association (AMA)
Espagnolle, Nicolas& Hebraud, Benjamin& Descamps, Jean-Gérard& Gadelorge, Mélanie& Joubert, Marie-Véronique& Ferreira, Laura Do Souto…[et al.]. Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1207721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207721