Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis
Joint Authors
Maacha, Selma
Sidahmed, Heba
Jacob, Shana
Gentilcore, Giusy
Calzone, Rita
Grivel, Jean-Charles
Cugno, Chiara
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
12
Abstract EN
The role of the mesenchymal stromal cell- (MSC-) derived secretome is becoming increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous tissue repair processes as well as its effective regulation of the immune system, mimicking the therapeutic effects produced by the MSCs.
The secretome is a composite product secreted by MSC in vitro (in conditioned medium) and in vivo (in the extracellular milieu), consisting of a protein soluble fraction (mostly growth factors and cytokines) and a vesicular component, extracellular vesicles (EVs), which transfer proteins, lipids, and genetic material.
MSC-derived secretome differs based on the tissue from which the MSCs are isolated and under specific conditions (e.g., preconditioning or priming) suggesting that clinical applications should be tailored by choosing the tissue of origin and a priming regimen to specifically correct a given pathology.
MSC-derived secretome mediates beneficial angiogenic effects in a variety of tissue injury-related diseases.
This supports the current effort to develop cell-free therapeutic products that bring both clinical benefits (reduced immunogenicity, persistence in vivo, and no genotoxicity associated with long-term cell cultures) and manufacturing advantages (reduced costs, availability of large quantities of off-the-shelf products, and lower regulatory burden).
In the present review, we aim to give a comprehensive picture of the numerous components of the secretome produced by MSCs derived from the most common tissue sources for clinical use (e.g., AT, BM, and CB).
We focus on the factors involved in the complex regulation of angiogenic processes.
American Psychological Association (APA)
Maacha, Selma& Sidahmed, Heba& Jacob, Shana& Gentilcore, Giusy& Calzone, Rita& Grivel, Jean-Charles…[et al.]. 2020. Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis. Stem Cells International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1207730
Modern Language Association (MLA)
Maacha, Selma…[et al.]. Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis. Stem Cells International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1207730
American Medical Association (AMA)
Maacha, Selma& Sidahmed, Heba& Jacob, Shana& Gentilcore, Giusy& Calzone, Rita& Grivel, Jean-Charles…[et al.]. Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1207730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207730