Involvement of Noncoding RNAs in the Differentiation of Osteoclasts
Joint Authors
Zhao, Yi
Jia, Lingfei
Zheng, Yunfei
Li, Weiran
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-25
Country of Publication
Egypt
No. of Pages
23
Abstract EN
As the most important bone-resorbing cells, osteoclasts play fundamental roles in bone remodeling and skeletal health.
Much effort has been focused on identifying the regulators of osteoclast metabolism.
Noncoding RNAs (ncRNAs) reportedly regulate osteoclast formation, differentiation, survival, and bone-resorbing activity to participate in bone physiology and pathology.
The present review intends to provide a general framework for how ncRNAs and their targets regulate osteoclast differentiation and the important events of osteoclastogenesis they are involved in, including osteoclast precursor generation, early differentiation, mononuclear osteoclast fusion, and multinucleated osteoclast function and survival.
This framework is beneficial for understanding bone biology and for identifying the potential biomarkers or therapeutic targets of bone diseases.
The review also summarizes the results of in vivo experiments and classic experiment methods for osteoclast-related researches.
American Psychological Association (APA)
Zhao, Yi& Jia, Lingfei& Zheng, Yunfei& Li, Weiran. 2020. Involvement of Noncoding RNAs in the Differentiation of Osteoclasts. Stem Cells International،Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1207764
Modern Language Association (MLA)
Zhao, Yi…[et al.]. Involvement of Noncoding RNAs in the Differentiation of Osteoclasts. Stem Cells International No. 2020 (2020), pp.1-23.
https://search.emarefa.net/detail/BIM-1207764
American Medical Association (AMA)
Zhao, Yi& Jia, Lingfei& Zheng, Yunfei& Li, Weiran. Involvement of Noncoding RNAs in the Differentiation of Osteoclasts. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-23.
https://search.emarefa.net/detail/BIM-1207764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207764