Organoids as a Powerful Model for Respiratory Diseases
Joint Authors
Chen, Huaiyong
Wu, Qi
Li, Yu
Sun, Xin
Shen, Jun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-11
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Insults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies.
Over the past decade, stem cell-derived self-organizing three-dimensional organoids have emerged as a new avenue to recapitulate respiratory diseases in a dish.
Alveolar organoids have improved our understanding of the mechanisms underlying tissue homeostasis and pathological alterations in alveoli.
From this perspective, we review the state-of-the-art technology on establishing alveolar organoids from endogenous lung epithelial stem/progenitor cells or pluripotent stem cells, as well as the use of alveolar organoids for the study of respiratory diseases, including idiopathic pulmonary fibrosis, tuberculosis infection, and respiratory virus infection.
We also discuss challenges that need to be overcome for future application of alveolar organoids in individualized medicine.
American Psychological Association (APA)
Li, Yu& Wu, Qi& Sun, Xin& Shen, Jun& Chen, Huaiyong. 2020. Organoids as a Powerful Model for Respiratory Diseases. Stem Cells International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1207820
Modern Language Association (MLA)
Li, Yu…[et al.]. Organoids as a Powerful Model for Respiratory Diseases. Stem Cells International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1207820
American Medical Association (AMA)
Li, Yu& Wu, Qi& Sun, Xin& Shen, Jun& Chen, Huaiyong. Organoids as a Powerful Model for Respiratory Diseases. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1207820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207820