iRoot SP Promotes OsteoOdontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways
Joint Authors
Fu, Lin
Wu, Xiao
Yan, Ming
Lu, Jiamin
Ge, Xingyun
Li, Yuzhi
Bian, Minxia
Yu, Jinhua
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-24
Country of Publication
Egypt
No. of Pages
15
Abstract EN
The regeneration of bone and tooth tissues, and related cellular therapies, has attracted widespread attention.
Bone marrow mesenchymal stem cells (BMSCs) are potential candidates for such regeneration.
iRoot SP is a premixed bioceramic root canal sealer widely used in clinical settings.
However, the effect of iRoot SP on the biological features of BMSCs has not been elucidated.
In the present study, we found that 0.2 mg/ml iRoot SP conditioned medium promoted osteo/odontogenic differentiation and enhanced mineralization of BMSCs without affecting the proliferative ability.
Mechanistically, the NF-κB and MAPK signaling pathways were activated in SP-treated BMSCs, and differentiation was inhibited when cultured with the specific inhibitor.
Taken together, these findings demonstrate that iRoot SP promotes osteo/odontogenic differentiation of BMSCs via the NF-κB and MAPK signaling pathways, which could provide a new theoretical basis for clinical applications of iRoot SP and a new therapeutic target for the regeneration of bone and tooth tissue in the future.
American Psychological Association (APA)
Wu, Xiao& Yan, Ming& Lu, Jiamin& Ge, Xingyun& Li, Yuzhi& Bian, Minxia…[et al.]. 2020. iRoot SP Promotes OsteoOdontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways. Stem Cells International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1207840
Modern Language Association (MLA)
Wu, Xiao…[et al.]. iRoot SP Promotes OsteoOdontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways. Stem Cells International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1207840
American Medical Association (AMA)
Wu, Xiao& Yan, Ming& Lu, Jiamin& Ge, Xingyun& Li, Yuzhi& Bian, Minxia…[et al.]. iRoot SP Promotes OsteoOdontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1207840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207840