RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt

Joint Authors

Liang, Changxiang
Liang, Guoyan
Zheng, Xiaoqing
Huang, Yongxiong
Huang, Shuaihao
Yin, Dong

Source

Stem Cells International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-04-06

Country of Publication

Egypt

No. of Pages

13

Abstract EN

Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity.

However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic.

RSP5, also called NEDD4L (NEDD4-like E3 ubiquitin protein ligase), belongs to the HECT (homologous to E6-AP carboxyl terminus) domain-containing E3 ligase family.

Nevertheless, although many studies have been conducted to elucidate the role of RSP5 in various biological processes, its effect on osteogenesis remains elusive.

In this study, we demonstrated that the expression of RSP5 was elevated during the osteogenesis of MSCs and positively regulated the osteogenic capacity of MSCs by inducing K63-linked polyubiquitination and activation of the Akt pathway.

Taken together, our findings suggest that RSP5 may be a promising target to improve therapeutic efficiency by using MSCs for bone regeneration and repair.

American Psychological Association (APA)

Liang, Changxiang& Liang, Guoyan& Zheng, Xiaoqing& Huang, Yongxiong& Huang, Shuaihao& Yin, Dong. 2020. RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt. Stem Cells International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207848

Modern Language Association (MLA)

Liang, Changxiang…[et al.]. RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt. Stem Cells International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1207848

American Medical Association (AMA)

Liang, Changxiang& Liang, Guoyan& Zheng, Xiaoqing& Huang, Yongxiong& Huang, Shuaihao& Yin, Dong. RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207848

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1207848