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RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt
Joint Authors
Liang, Changxiang
Liang, Guoyan
Zheng, Xiaoqing
Huang, Yongxiong
Huang, Shuaihao
Yin, Dong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-06
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity.
However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic.
RSP5, also called NEDD4L (NEDD4-like E3 ubiquitin protein ligase), belongs to the HECT (homologous to E6-AP carboxyl terminus) domain-containing E3 ligase family.
Nevertheless, although many studies have been conducted to elucidate the role of RSP5 in various biological processes, its effect on osteogenesis remains elusive.
In this study, we demonstrated that the expression of RSP5 was elevated during the osteogenesis of MSCs and positively regulated the osteogenic capacity of MSCs by inducing K63-linked polyubiquitination and activation of the Akt pathway.
Taken together, our findings suggest that RSP5 may be a promising target to improve therapeutic efficiency by using MSCs for bone regeneration and repair.
American Psychological Association (APA)
Liang, Changxiang& Liang, Guoyan& Zheng, Xiaoqing& Huang, Yongxiong& Huang, Shuaihao& Yin, Dong. 2020. RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt. Stem Cells International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207848
Modern Language Association (MLA)
Liang, Changxiang…[et al.]. RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt. Stem Cells International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1207848
American Medical Association (AMA)
Liang, Changxiang& Liang, Guoyan& Zheng, Xiaoqing& Huang, Yongxiong& Huang, Shuaihao& Yin, Dong. RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207848