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Dental Stem Cell-Derived SecretomeConditioned Medium: The Future for Regenerative Therapeutic Applications
Joint Authors
Fawzy El-Sayed, Karim M.
Dörfer, Christof E.
Radwan, Israa Ahmed
Rady, Dina
Abbass, Marwa M. S.
El Moshy, Sara
El-Rashidy, Aiah A.
Sadek, Khadiga M.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-29, 29 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
29
Abstract EN
Regenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects.
Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with minimally invasive procedures.
Their mechanism of action has been attributed to their cell-to-cell contacts as well as to the paracrine effect of their secreted factors, namely, secretome.
In this context, dental MSC-derived secretome/conditioned medium could represent a unique cell-free regenerative and therapeutic approach, with fascinating advantages over parent cells.
This article reviews the application of different populations of dental MSC secretome/conditioned medium in in vitro and in vivo animal models, highlights their significant implementation in treating different tissue’ diseases, and clarifies the significant bioactive molecules involved in their regenerative potential.
The analysis of these recent studies clearly indicate that dental MSCs’ secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators.
American Psychological Association (APA)
El Moshy, Sara& Radwan, Israa Ahmed& Rady, Dina& Abbass, Marwa M. S.& El-Rashidy, Aiah A.& Sadek, Khadiga M.…[et al.]. 2020. Dental Stem Cell-Derived SecretomeConditioned Medium: The Future for Regenerative Therapeutic Applications. Stem Cells International،Vol. 2020, no. 2020, pp.1-29.
https://search.emarefa.net/detail/BIM-1207865
Modern Language Association (MLA)
El Moshy, Sara…[et al.]. Dental Stem Cell-Derived SecretomeConditioned Medium: The Future for Regenerative Therapeutic Applications. Stem Cells International No. 2020 (2020), pp.1-29.
https://search.emarefa.net/detail/BIM-1207865
American Medical Association (AMA)
El Moshy, Sara& Radwan, Israa Ahmed& Rady, Dina& Abbass, Marwa M. S.& El-Rashidy, Aiah A.& Sadek, Khadiga M.…[et al.]. Dental Stem Cell-Derived SecretomeConditioned Medium: The Future for Regenerative Therapeutic Applications. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-29.
https://search.emarefa.net/detail/BIM-1207865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207865