Amygdalin Promotes Fracture Healing through TGF-βSmad Signaling in Mesenchymal Stem Cells
Joint Authors
Chen, Di
Xu, Taotao
Xiao, Luwei
Tong, Peijian
Ying, Jun
Hu, Songfeng
Luo, Cheng
Shen, Jie
Ge, Qinwen
Lu, Fengyi
Yu, Yikang
Lv, Shuaijie
Li, Ju
Jin, Hongting
Wang, Pinger
Zhang, Lei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Chondrogenesis and subsequent osteogenesis of mesenchymal stem cells (MSCs) and angiogenesis at injured sites are crucial for bone fracture healing.
Amygdalin, a cyanogenic glycoside compound derived from bitter apricot kernel, has been reported to inhibit IL-1β-induced chondrocyte degeneration and to stimulate blood circulation, suggesting a promising role of amygdalin in fracture healing.
In this study, tibial fractures in C57BL/6 mice were treated with amygdalin.
Fracture calluses were then harvested and subjected to radiographic, histological, and biomechanical testing, as well as angiography and gene expression analyses to evaluate fracture healing.
The results showed that amygdalin treatment promoted bone fracture healing.
Further experiments using MSC-specific transforming growth factor- (TGF-) β receptor 2 conditional knockout (KO) mice (Tgfbr2Gli1-Cre) and C3H10 T1/2 murine mesenchymal progenitor cells showed that this effect was mediated through TGF-β/Smad signaling.
We conclude that amygdalin could be used as an alternative treatment for bone fractures.
American Psychological Association (APA)
Ying, Jun& Ge, Qinwen& Hu, Songfeng& Luo, Cheng& Lu, Fengyi& Yu, Yikang…[et al.]. 2020. Amygdalin Promotes Fracture Healing through TGF-βSmad Signaling in Mesenchymal Stem Cells. Stem Cells International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207898
Modern Language Association (MLA)
Ying, Jun…[et al.]. Amygdalin Promotes Fracture Healing through TGF-βSmad Signaling in Mesenchymal Stem Cells. Stem Cells International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1207898
American Medical Association (AMA)
Ying, Jun& Ge, Qinwen& Hu, Songfeng& Luo, Cheng& Lu, Fengyi& Yu, Yikang…[et al.]. Amygdalin Promotes Fracture Healing through TGF-βSmad Signaling in Mesenchymal Stem Cells. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1207898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207898