Sinusoidal Endothelial Cell Progenitor Cells Promote Tumour Progression in Patients with Hepatocellular Carcinoma
Joint Authors
Feng, Ya-xing
Li, Wei
Wen, Xu-dong
Zhang, Ning
Liu, Wei-hui
Yang, Zhan-yu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-29
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Objective.
As sinusoidal endothelial cell progenitor cells (SEPCs) play a significant role in liver regeneration, it is necessary to elucidate whether SEPCs participate in tumour progression of hepatocellular carcinoma (HCC).
Methods.
A total of 45 patients with primary HCC who underwent liver resection were included in this study.
The liver tumours were removed from the patients, and partial tissues were prepared to identify SEPCs through double staining of CD133/CD45 and CD133/CD31 at the same location.
Blood samples were collected to examine liver function parameters and tumour markers.
The demographics and clinicopathological characteristics of the patients were collected for correlation analysis with SEPCs.
Results.
SEPCs were observed in several blood vessels within the HCC nodules of all 45 patients, but no SEPCs were detected in the tumour-adjacent tissues.
The number of SEPCs was correlated with the expression levels of HCC tumour markers α-fetoprotein (AFP) and CA199.
There was a positive correlation between the expression of SEPC markers and diameter of HCC tumours in differently differentiated specimens (P<0.01).
The expression levels of SEPC markers were significantly higher in patients with poorly differentiated HCC than in patients with moderately and highly differentiated HCC (P<0.05).
Conclusions.
SEPCs are closely associated with HCC progression; therefore, SEPCs may be considered potential prognostic and metastatic biomarkers and therapeutic candidates for HCC.
American Psychological Association (APA)
Feng, Ya-xing& Li, Wei& Wen, Xu-dong& Zhang, Ning& Liu, Wei-hui& Yang, Zhan-yu. 2020. Sinusoidal Endothelial Cell Progenitor Cells Promote Tumour Progression in Patients with Hepatocellular Carcinoma. Stem Cells International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1207906
Modern Language Association (MLA)
Feng, Ya-xing…[et al.]. Sinusoidal Endothelial Cell Progenitor Cells Promote Tumour Progression in Patients with Hepatocellular Carcinoma. Stem Cells International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1207906
American Medical Association (AMA)
Feng, Ya-xing& Li, Wei& Wen, Xu-dong& Zhang, Ning& Liu, Wei-hui& Yang, Zhan-yu. Sinusoidal Endothelial Cell Progenitor Cells Promote Tumour Progression in Patients with Hepatocellular Carcinoma. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1207906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207906