Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential
Joint Authors
Zhao, Ashley G.
Shah, Kiran
Cromer, Brett
Sumer, Huseyin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-24
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Extracellular vesicles (EVs) are cell-derived membrane-bound nanoparticles, which act as shuttles, delivering a range of biomolecules to diverse target cells.
They play an important role in maintenance of biophysiological homeostasis and cellular, physiological, and pathological processes.
EVs have significant diagnostic and therapeutic potentials and have been studied both in vitro and in vivo in many fields.
Mesenchymal stem cells (MSCs) are multipotent cells with many therapeutic applications and have also gained much attention as prolific producers of EVs.
MSC-derived EVs are being explored as a therapeutic alternative to MSCs since they may have similar therapeutic effects but are cell-free.
They have applications in regenerative medicine and tissue engineering and, most importantly, confer several advantages over cells such as lower immunogenicity, capacity to cross biological barriers, and less safety concerns.
In this review, we introduce the biogenesis of EVs, including exosomes and microvesicles.
We then turn more specifically to investigations of MSC-derived EVs.
We highlight the great therapeutic potential of MSC-derived EVs and applications in regenerative medicine and tissue engineering.
American Psychological Association (APA)
Zhao, Ashley G.& Shah, Kiran& Cromer, Brett& Sumer, Huseyin. 2020. Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential. Stem Cells International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207916
Modern Language Association (MLA)
Zhao, Ashley G.…[et al.]. Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential. Stem Cells International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1207916
American Medical Association (AMA)
Zhao, Ashley G.& Shah, Kiran& Cromer, Brett& Sumer, Huseyin. Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207916