Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis
Joint Authors
Wang, Ruoxi
Zhu, Lisha
Liu, Yan
Li, Weiran
Wang, Yu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-10
Country of Publication
Egypt
No. of Pages
17
Abstract EN
Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions.
However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a senescent status with impaired self-renewal capacity and biased differentiation tendency.
MSC functional decline accounts for the pathogenesis of many diseases and, more importantly, limits the large-scale applications of MSCs in regenerative medicine.
Growing evidence implies that epigenetic mechanisms are a critical regulator of the differentiation programs for cell fate and are subject to changes during aging.
Thus, we here review epigenetic dysregulations that contribute to MSC aging and osteoporosis.
Comprehending detailed epigenetic mechanisms could provide us with a novel horizon for dissecting MSC-related pathogenesis and further optimizing MSC-mediated regenerative therapies.
American Psychological Association (APA)
Wang, Ruoxi& Wang, Yu& Zhu, Lisha& Liu, Yan& Li, Weiran. 2020. Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis. Stem Cells International،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1207942
Modern Language Association (MLA)
Wang, Ruoxi…[et al.]. Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis. Stem Cells International No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1207942
American Medical Association (AMA)
Wang, Ruoxi& Wang, Yu& Zhu, Lisha& Liu, Yan& Li, Weiran. Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1207942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207942