Mesenchymal StemProgenitor Cells: The Prospect of Human Clinical Translation
Joint Authors
Dörfer, Christof E.
Rady, Dina
Abbass, Marwa M. S.
El-Rashidy, Aiah A.
El Moshy, Sara
Radwan, Israa Ahmed
Fawzy El-Sayed, Karim M.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-45, 45 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-11
Country of Publication
Egypt
No. of Pages
45
Abstract EN
Mesenchymal stem/progenitor cells (MSCs) are key players in regenerative medicine, relying principally on their differentiation/regeneration potential, immunomodulatory properties, paracrine effects, and potent homing ability with minimal if any ethical concerns.
Even though multiple preclinical and clinical studies have demonstrated remarkable properties for MSCs, the clinical applicability of MSC-based therapies is still questionable.
Several challenges exist that critically hinder a successful clinical translation of MSC-based therapies, including but not limited to heterogeneity of their populations, variability in their quality and quantity, donor-related factors, discrepancies in protocols for isolation, in vitro expansion and premodification, and variability in methods of cell delivery, dosing, and cell homing.
Alterations of MSC viability, proliferation, properties, and/or function are also affected by various drugs and chemicals.
Moreover, significant safety concerns exist due to possible teratogenic/neoplastic potential and transmission of infectious diseases.
Through the current review, we aim to highlight the major challenges facing MSCs’ human clinical translation and shed light on the undergoing strategies to overcome them.
American Psychological Association (APA)
Rady, Dina& Abbass, Marwa M. S.& El-Rashidy, Aiah A.& El Moshy, Sara& Radwan, Israa Ahmed& Dörfer, Christof E.…[et al.]. 2020. Mesenchymal StemProgenitor Cells: The Prospect of Human Clinical Translation. Stem Cells International،Vol. 2020, no. 2020, pp.1-45.
https://search.emarefa.net/detail/BIM-1207946
Modern Language Association (MLA)
Rady, Dina…[et al.]. Mesenchymal StemProgenitor Cells: The Prospect of Human Clinical Translation. Stem Cells International No. 2020 (2020), pp.1-45.
https://search.emarefa.net/detail/BIM-1207946
American Medical Association (AMA)
Rady, Dina& Abbass, Marwa M. S.& El-Rashidy, Aiah A.& El Moshy, Sara& Radwan, Israa Ahmed& Dörfer, Christof E.…[et al.]. Mesenchymal StemProgenitor Cells: The Prospect of Human Clinical Translation. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-45.
https://search.emarefa.net/detail/BIM-1207946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207946