Effect of Fe3O4 Nanoparticles on Mixed POPCDPPC Monolayers at Air-Water Interface
Joint Authors
Hao, Changchun
Xu, Zhuangwei
Xie, Bin
Sun, Runguang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Information Technology and Computer Science
Abstract EN
Fe3O4 nanoparticles (NPs) as a commonly used carrier in targeted drug delivery are widely used to carry drugs for the treatment of diseases.
However, the mechanism of action of between Fe3O4 NPs and biological membranes is still unclear.
Therefore, this article reports the influence of hydrophilic and hydrophobic Fe3O4 NPs on mixed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) that were studied using the Langmuir-Blodgett (LB) film technique and an atomic force microscope (AFM).
From surface pressure-area (π-A) isotherms, we have calculated the compression modulus.
The results showed that hydrophobic Fe3O4 NPs enlarged the liquid-expanded (LE) and liquid-condensed (LC) phase of the mixed POPC/DPPC monolayers.
The compressibility modulus of the mixed POPC/DPPC monolayer increases for hydrophilic Fe3O4 NPs, but the opposite happens for the hydrophobic Fe3O4 NPs.
The adsorption of hydrophobic Fe3O4 NPs in mixed POPC/DPPC monolayers was much more than the hydrophilic Fe3O4 NPs.
The interaction of hydrophilic Fe3O4 NPs with the head polar group of the mixed lipids increased the attraction force among the molecules, while the interaction of hydrophobic Fe3O4 NPs with the tail chain of the mixed lipids enhanced the repulsive force.
The morphology of the monolayers was observed by AFM for validating the inferred results.
This study is of great help for the application of Fe3O4 NPs in biological systems.
American Psychological Association (APA)
Xu, Zhuangwei& Hao, Changchun& Xie, Bin& Sun, Runguang. 2019. Effect of Fe3O4 Nanoparticles on Mixed POPCDPPC Monolayers at Air-Water Interface. Scanning،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207984
Modern Language Association (MLA)
Xu, Zhuangwei…[et al.]. Effect of Fe3O4 Nanoparticles on Mixed POPCDPPC Monolayers at Air-Water Interface. Scanning No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1207984
American Medical Association (AMA)
Xu, Zhuangwei& Hao, Changchun& Xie, Bin& Sun, Runguang. Effect of Fe3O4 Nanoparticles on Mixed POPCDPPC Monolayers at Air-Water Interface. Scanning. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1207984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207984