Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance
Joint Authors
Ye, Ping
Xu, Ling
Chen, Lu
Huang, Yan
Chen, Guo-Qing
Ling, Rong-Song
Zeng, Fa
Zhu, Xiong-Shan
Xie, Xiao-Ying
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-29
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Ovarian cancer is a highly deadly disease, which is often diagnosed at a late stage with metastases.
However, most ovarian cancers relapse after surgery combined with platinum-based chemotherapy.
Cancer stem cells (CSCs) are stem-like cells that possess high tumorigenic capability and display higher resistant capability against current therapies.
However, our knowledge of ovarian CSCs and their molecular mechanism remains sparse.
In the current study, we found that KDM4C, a histone demethylase, was required for ovarian cancer stem cell (CSC) maintenance.
Depletion of KDM4C significantly reduced the CSC population and sphere formation in vitro.
Moreover, we found that KDM4C can regulate the expression of stem cell factor OCT-4 via binding to its promoter.
These data indicate that KDM4C is relevant for ovarian CSC maintenance and underscore its importance as a potential therapeutic target.
American Psychological Association (APA)
Chen, Guo-Qing& Ye, Ping& Ling, Rong-Song& Zeng, Fa& Zhu, Xiong-Shan& Chen, Lu…[et al.]. 2020. Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance. Stem Cells International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208000
Modern Language Association (MLA)
Chen, Guo-Qing…[et al.]. Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance. Stem Cells International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1208000
American Medical Association (AMA)
Chen, Guo-Qing& Ye, Ping& Ling, Rong-Song& Zeng, Fa& Zhu, Xiong-Shan& Chen, Lu…[et al.]. Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208000