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Mesenchymal Stem Cells as Therapeutic Agents and Novel Carriers for the Delivery of Candidate Genes in Acute Kidney Injury
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-11
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Acute kidney injury (AKI) is a heterogeneous syndrome characterized by a dramatic increase in serum creatinine.
Mild AKI may merely be confined to kidney damage and resolve within days; however, severe AKI commonly involves extrarenal organ dysfunction and is associated with high mortality.
There is no specific pharmaceutical treatment currently available that can reverse the course of this disease.
Notably, mesenchymal stem cells (MSCs) show great promise for the management of AKI by targeting multiple pathophysiological pathways to facilitate tubular epithelial cell repair.
It has been well established that the unique characteristics of MSCs make them ideal vectors for gene therapy.
Thus, genetic modification has been attempted to achieve improved therapeutic outcomes in the management of AKI by overexpressing trophic cytokines or facilitating MSC delivery to renal tissues.
The present article provides a comprehensive review of genetic modification strategies targeted at optimizing the therapeutic potential of MSCs in AKI.
American Psychological Association (APA)
Liu, Yuxiang& Fang, Jingai. 2020. Mesenchymal Stem Cells as Therapeutic Agents and Novel Carriers for the Delivery of Candidate Genes in Acute Kidney Injury. Stem Cells International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208033
Modern Language Association (MLA)
Liu, Yuxiang& Fang, Jingai. Mesenchymal Stem Cells as Therapeutic Agents and Novel Carriers for the Delivery of Candidate Genes in Acute Kidney Injury. Stem Cells International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1208033
American Medical Association (AMA)
Liu, Yuxiang& Fang, Jingai. Mesenchymal Stem Cells as Therapeutic Agents and Novel Carriers for the Delivery of Candidate Genes in Acute Kidney Injury. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1208033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208033