Bmi1 Severs as a Potential Tumor-Initiating Cell Marker and Therapeutic Target in Esophageal Squamous Cell Carcinoma

Abstract EN

Esophageal squamous cell carcinoma (ESCC) is a frequent malignant tumor with low 5-year overall survival.

Targeting ESCC tumor-initiating cells (TICs) may provide a new research avenue to achieve better therapeutic effects of ESCC.

However, the identity and characteristics of ESCC TICs remain poorly understood.

Through genetic lineage tracing approach, we found that a group of Moloney murine leukemia virus insertion site 1- (Bmi1-) expressing cell populations present in the invasive front of the esophageal epithelium, providing a continuous flow of tumor cells for ESCC.

Subsequently, we found that ablation of Bmi1+ cells from mice with ESCC led to inhibition of tumor growth.

In addition, our results demonstrated that PTC-209, an inhibitor of Bmi1, was able to inhibit ESCC progression when combined with cisplatin.

In summary, our data suggest that Bmi1+ cells serve as TICs in ESCC.