The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review
Joint Authors
Evens, Lize
Beliën, Hanne
Deluyker, Dorien
Bronckaers, Annelies
Gervois, Pascal
Hendrikx, Marc
Bito, Virginie
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Stem cell-based regenerative therapies hold great promises to treat a wide spectrum of diseases.
However, stem cell engraftment and survival are still challenging due to an unfavorable transplantation environment.
Advanced glycation end-products (AGEs) can contribute to the generation of these harmful conditions.
AGEs are a heterogeneous group of glycated products, nonenzymatically formed when proteins and/or lipids become glycated and oxidized.
Our typical Western diet as well as cigarettes contain high AGEs content.
AGEs are also endogenously formed in our body and accumulate with senescence and in pathological situations.
Whether AGEs have an impact on stem cell viability in regenerative medicine remains unclear, and research on the effect of AGEs on stem cell proliferation and apoptosis is still ongoing.
Therefore, this systematic review provides a clear overview of the effects of glycated proteins on cell viability in various types of primary isolated stem cells used in regenerative medicine.
American Psychological Association (APA)
Evens, Lize& Beliën, Hanne& Deluyker, Dorien& Bronckaers, Annelies& Gervois, Pascal& Hendrikx, Marc…[et al.]. 2020. The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review. Stem Cells International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1208064
Modern Language Association (MLA)
Evens, Lize…[et al.]. The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review. Stem Cells International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1208064
American Medical Association (AMA)
Evens, Lize& Beliën, Hanne& Deluyker, Dorien& Bronckaers, Annelies& Gervois, Pascal& Hendrikx, Marc…[et al.]. The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1208064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208064