Humoral Influence of Repeated Lineage-Negative StemProgenitor Cell Administration on Articulatory Functions in ALS Patients
Joint Authors
Safranow, Krzysztof
Golab-Janowska, Monika
Nowacki, Przemyslaw
Sobuś, Anna
Baumert, Bartłomiej
Pawlukowska, Wioletta
Paczkowska, Edyta
Wełnicka, Agnieszka
Meller, Agnieszka
Machowska-Sempruch, Karolina
Zawiślak, Alicja
Łuczkowska, Karolina
Milczarek, Sławomir
Osękowska, Bogumiła
Rotter, Iwona
Machaliński, Bogusław
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-15
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Amyotrophic lateral sclerosis (ALS) remains a fatal, neurodegenerative disease frequently leading to dysarthria and impaired swallowing.
Better understanding of ALS pathophysiology is prompting the use of humoral cell therapies.
Hence, a repeated cellular therapy was applied to ALS patients as an attempt to prevent speech deterioration.
Autologous bone marrow-derived lineage-negative (Lin−) cells were intrathecally administered three times at six-week intervals to 42 sporadic ALS patients.
Patients were examined for articulatory functions using subjective (VHI) and objective (FDA) scales.
Selected trophic, proinflammatory factors and expression profiles of miRNA were measured in cerebrospinal fluid (CSF) and plasma by multiplex Luminex and q-PCR in different timepoints.
Of the 42 patients who received the Lin− cells, 6 showed improvement in articulatory functions, 27 remained stable, and 9 deteriorated after 18 weeks of therapy according to FDA scale.
Clinical improvement was particularly evident by the 7th day of each cell application and concerned better cough and swallow reflex, soft palate, laryngeal time, pitch, and volume.
These results correlated with significant changes in the concentration of various trophic and proinflammatory factors and miRNA expression profiles.
A multiple application of Lin− cells proved to be safe and feasible.
The repeated procedure can potentate a humoral effect and prevent speech deterioration.
A short-lasting trophic effect of each Lin− cells administration was observed on local and systemic level.
However, further in-depth studies are necessary to sustain the beneficial effect.
American Psychological Association (APA)
Sobuś, Anna& Baumert, Bartłomiej& Pawlukowska, Wioletta& Golab-Janowska, Monika& Paczkowska, Edyta& Wełnicka, Agnieszka…[et al.]. 2020. Humoral Influence of Repeated Lineage-Negative StemProgenitor Cell Administration on Articulatory Functions in ALS Patients. Stem Cells International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1208065
Modern Language Association (MLA)
Sobuś, Anna…[et al.]. Humoral Influence of Repeated Lineage-Negative StemProgenitor Cell Administration on Articulatory Functions in ALS Patients. Stem Cells International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1208065
American Medical Association (AMA)
Sobuś, Anna& Baumert, Bartłomiej& Pawlukowska, Wioletta& Golab-Janowska, Monika& Paczkowska, Edyta& Wełnicka, Agnieszka…[et al.]. Humoral Influence of Repeated Lineage-Negative StemProgenitor Cell Administration on Articulatory Functions in ALS Patients. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1208065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208065