Stem Cell Therapy for Neurodegenerative Diseases: How Do Stem Cells Bypass the Blood-Brain Barrier and Home to the Brain?
Joint Authors
Chia, Yvonne Cashinn
Anjum, Clarice Evey
Yee, Hui Rong
Kenisi, Yenny
Chan, Mike K. S.
Wong, Michelle B. F.
Pan, Shing Yi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-04
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Blood-brain barrier (BBB) is a term describing the highly selective barrier formed by the endothelial cells (ECs) of the central nervous system (CNS) homeostasis by restricting movement across the BBB.
An intact BBB is critical for normal brain functions as it maintains brain homeostasis, modulates immune cell transport, and provides protection against pathogens and other foreign substances.
However, it also prevents drugs from entering the CNS to treat neurodegenerative diseases.
Stem cells, on the other hand, have been reported to bypass the BBB and successfully home to their target in the brain and initiate repair, making them a promising approach in cellular therapy, especially those related to neurodegenerative disease.
This review article discusses the mechanism behind the successful homing of stem cells to the brain, their potential role as a drug delivery vehicle, and their applications in neurodegenerative diseases.
American Psychological Association (APA)
Chia, Yvonne Cashinn& Anjum, Clarice Evey& Yee, Hui Rong& Kenisi, Yenny& Chan, Mike K. S.& Wong, Michelle B. F.…[et al.]. 2020. Stem Cell Therapy for Neurodegenerative Diseases: How Do Stem Cells Bypass the Blood-Brain Barrier and Home to the Brain?. Stem Cells International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1208067
Modern Language Association (MLA)
Chia, Yvonne Cashinn…[et al.]. Stem Cell Therapy for Neurodegenerative Diseases: How Do Stem Cells Bypass the Blood-Brain Barrier and Home to the Brain?. Stem Cells International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1208067
American Medical Association (AMA)
Chia, Yvonne Cashinn& Anjum, Clarice Evey& Yee, Hui Rong& Kenisi, Yenny& Chan, Mike K. S.& Wong, Michelle B. F.…[et al.]. Stem Cell Therapy for Neurodegenerative Diseases: How Do Stem Cells Bypass the Blood-Brain Barrier and Home to the Brain?. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1208067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208067