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Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective
Joint Authors
Xie, Jiang
Wang, Mengyuan
Wang, Cong
Zhong, Dingping
Xie, Liang
Fang, Hongzhi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-08
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Periodontitis is the sixth-most prevalent chronic inflammatory disease and gradually devastates tooth-supporting tissue.
The complexity of periodontal tissue and the local inflammatory microenvironment poses great challenges to tissue repair.
Recently, stem cells have been considered a promising strategy to treat tissue damage and inflammation because of their remarkable properties, including stemness, proliferation, migration, multilineage differentiation, and immunomodulation.
Several varieties of stem cells can potentially be applied to periodontal regeneration, including dental mesenchymal stem cells (DMSCs), nonodontogenic stem cells, and induced pluripotent stem cells (iPSCs).
In particular, these stem cells possess extensive immunoregulatory capacities.
In periodontitis, these cells can exert anti-inflammatory effects and regenerate the periodontium.
Stem cells derived from infected tissue possess typical stem cell characteristics with lower immunogenicity and immunosuppression.
Several studies have demonstrated that these cells can also regenerate the periodontium.
Furthermore, the interaction of stem cells with the surrounding infected microenvironment is critical to periodontal tissue repair.
Though the immunomodulatory capabilities of stem cells are not entirely clarified, they show promise for therapeutic application in periodontitis.
Here, we summarize the potential of stem cells for periodontium regeneration in periodontitis and focus on their characteristics and immunomodulatory properties as well as challenges and perspectives.
American Psychological Association (APA)
Wang, Mengyuan& Xie, Jiang& Wang, Cong& Zhong, Dingping& Xie, Liang& Fang, Hongzhi. 2020. Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective. Stem Cells International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1208111
Modern Language Association (MLA)
Wang, Mengyuan…[et al.]. Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective. Stem Cells International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1208111
American Medical Association (AMA)
Wang, Mengyuan& Xie, Jiang& Wang, Cong& Zhong, Dingping& Xie, Liang& Fang, Hongzhi. Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1208111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208111