In Vivo Comparison of Chlorine-Based Antiseptics versus Alcohol Antiseptic for Surgical Hand Antisepsis
Joint Authors
Myltykbayeva, Zhannur
Kovaleva, Galina
Mukhitdinov, Azamat
Omarova, Sandugash
Nadirov, Rashid
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Despite being commonly used as effective preparation for surgical hand antisepsis, alcohol solutions have major drawbacks, such as drying effect, emergence of hand eczema, and other diseases.
This study aimed to demonstrate the effectiveness of sodium hypochlorite (NaOCl) and hydrogen peroxide (H2O2) as antiseptic in comparison to single sodium hypochlorite and 70% ethanol.
In 5-day tests, the effects of 3 antiseptics were established according to standard test methods.
The antiseptics were applied to the hands of 82 volunteers, and samples of bacteria were collected on days 1 and 5, immediately after drying and 6 hours later after antiseptic application.
Student’s t test and ANOVA were applied in a statistical study.
The NaOCl with H2O2 composition demonstrated noninferiority to both sodium hypochlorite only and alcohol products and superiority to these antiseptics on day 5 (P<0.05 at a significance level of 5% for each comparative trial in this day) at equivalence margin of 20%.
The effectiveness of the NaOCl plus H2O2 composition as an antiseptic was explained by the formation of singlet oxygen in the system.
Together, these data suggest that NaOCl and H2O2 may be an effective hand antisepsis that avoids the drawbacks seen with alcohol solutions.
American Psychological Association (APA)
Myltykbayeva, Zhannur& Kovaleva, Galina& Mukhitdinov, Azamat& Omarova, Sandugash& Nadirov, Rashid. 2020. In Vivo Comparison of Chlorine-Based Antiseptics versus Alcohol Antiseptic for Surgical Hand Antisepsis. Scientifica،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1208145
Modern Language Association (MLA)
Myltykbayeva, Zhannur…[et al.]. In Vivo Comparison of Chlorine-Based Antiseptics versus Alcohol Antiseptic for Surgical Hand Antisepsis. Scientifica No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1208145
American Medical Association (AMA)
Myltykbayeva, Zhannur& Kovaleva, Galina& Mukhitdinov, Azamat& Omarova, Sandugash& Nadirov, Rashid. In Vivo Comparison of Chlorine-Based Antiseptics versus Alcohol Antiseptic for Surgical Hand Antisepsis. Scientifica. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1208145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208145