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Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Breast cancer is the most commonly diagnosed form of cancer in women comprising 16% of all female cancers.
The disease shows high intertumoral and intratumoral heterogeneity posing diagnostic and therapeutic challenges with unpredictable clinical outcome and response to existing therapy.
Mounting evidence is ascertaining that breast cancer stem cells (CSCs) are responsible for tumor initiation, progression, recurrence, evolution, metastasis, and drug resistance.
Therapeutics selectively targeting the CSCs based on distinct surface molecular markers and enhanced intracellular activities of these cells continue to evolve and hold significant promise.
Having plethora of heterogeneity accompanied with failure of existing conventional therapeutics and poor prognosis, the present review focuses on elucidating the main signaling pathways in breast CSCs as major therapeutic targets.
The role of developments in nanomedicine and miRNA as targeted delivery of therapeutic anticancer agents is also highlighted.
American Psychological Association (APA)
Tuasha, Nigatu& Petros, Beyene. 2020. Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics. Scientifica،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1208188
Modern Language Association (MLA)
Tuasha, Nigatu& Petros, Beyene. Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics. Scientifica No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1208188
American Medical Association (AMA)
Tuasha, Nigatu& Petros, Beyene. Heterogeneity of Tumors in Breast Cancer: Implications and Prospects for Prognosis and Therapeutics. Scientifica. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1208188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208188