Obtaining and Investigation of the β-Cyclodextrin Inclusion Complex with Vitamin D3 Oil Solution

Abstract EN

Background.

The research results of fat-soluble vitamin D3 (cholecalciferol) encapsulation with β-cyclodextrin have been presented in this work.

The vitamin D3 inclusion complex with β-cyclodextrin was obtained under microwave radiation.

The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope.

The thermographic measurement results on a differential scanning calorimeter have been presented.

The activation energy of the β-cyclodextrin : vitamin D3 clathrate complex thermal oxidative destruction reaction was calculated.

The clathrate thermal destruction kinetic parameters were determined.

The inclusion complex spectral properties were characterized by IR-Fourier and 1H and 13C NMR spectroscopy.

The existence of β-cyclodextrin inclusion complex with vitamin D3 in a 2 : 1 ratio was confirmed by the experimental results.

The activation energy of thermal destruction of the inclusion complex of β-cyclodextrin with vitamin D3 was calculated using four different methods.