Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves
Joint Authors
Trabelsi, Amine
El Kaibi, Mohamed Amine
Abbassi, Aïmen
Horchani, Amira
Chekir-Ghedira, Leila
Ghedira, Kamel
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study aimed to determine phytochemical contents, antibacterial properties, and antibiotic modulating potential of Punica granatum leaf extracts: hexane, chloroform, ethyl acetate, ethanol, and aqueous extracts as well as an extract enriched with total oligomer flavonoids (TOFs).
The TOF extract contained the highest value of phenols and flavonoids.
Rutin, luteolin, gallic acid, and ellagic acid were determined by HPLC analysis of this extract.
The antibacterial activity was assayed by the disc diffusion method and microdilution method against Staphylococcus aureus and Escherichia coli standard ATCC strains and clinical isolates resistant strains.
The TOF extract was the most active against all tested strains.
The checkerboard method was used for the determination of synergy between two antibiotics (amoxicillin and cefotaxime) and P.
granatum leaf extracts.
The best synergistic interaction was found with TOF extract combined with amoxicillin for penicillin-resistant E.
coli and penicillin-resistant S.
aureus.
These results can be assigned to tannins, flavonoids, and phenolic acids found in P.
granatum leaf extracts.
Pomegranate leaf extracts or active compounds isolated from these extracts could be used to fight the emergence and spread of resistant bacterial strains.
American Psychological Association (APA)
Trabelsi, Amine& El Kaibi, Mohamed Amine& Abbassi, Aïmen& Horchani, Amira& Chekir-Ghedira, Leila& Ghedira, Kamel. 2020. Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves. Scientifica،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208245
Modern Language Association (MLA)
Trabelsi, Amine…[et al.]. Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves. Scientifica No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1208245
American Medical Association (AMA)
Trabelsi, Amine& El Kaibi, Mohamed Amine& Abbassi, Aïmen& Horchani, Amira& Chekir-Ghedira, Leila& Ghedira, Kamel. Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves. Scientifica. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1208245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208245