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Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation
Joint Authors
Jung, Haiyoung
Lee, Jungwoon
Park, Young-Jun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-24
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Protein kinases modulate the reversible postmodifications of substrate proteins to their phosphorylated forms as an essential process in regulating intracellular signaling transduction cascades.
Moreover, phosphorylation has recently been shown to tightly control the regulatory network of kinases responsible for the induction and maintenance of pluripotency, defined as the particular ability to differentiate pluripotent stem cells (PSCs) into every cell type in the adult body.
In particular, emerging evidence indicates that the balance between the self-renewal and differentiation of PSCs is regulated by the small molecules that modulate kinase signaling pathways.
Furthermore, new reprogramming technologies have been developed using kinase modulators, which have provided novel insight of the mechanisms underlying the kinase regulatory networks involved in the generation of induced pluripotent stem cells (iPSCs).
In this review, we highlight the recent progress made in defining the roles of protein kinase signaling pathways and their small molecule modulators in regulating the pluripotent states, self-renewal, reprogramming process, and lineage differentiation of PSCs.
American Psychological Association (APA)
Lee, Jungwoon& Park, Young-Jun& Jung, Haiyoung. 2019. Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation. Stem Cells International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208250
Modern Language Association (MLA)
Lee, Jungwoon…[et al.]. Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation. Stem Cells International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1208250
American Medical Association (AMA)
Lee, Jungwoon& Park, Young-Jun& Jung, Haiyoung. Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208250