![](/images/graphics-bg.png)
The Potential Role of Quorum Sensing in Clonal Growth and Subsequent Expansion of Bone Marrow Stromal Cell Strains in Culture
Joint Authors
Pierelli, Luca
Sacchetti, Benedetto
Alimandi, Maurizio
Pino, Valentina
Gentileschi, Stefano
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Clonal development (clonogenicity) is an inherent property of a subset of postnatal bone marrow (BM) adherent stromal mesenchymal stem cells (MSCs) from which a multipotent progeny develops in culture.
Our data suggest that clonogenicity and BM-MSC expansion are two distinct biological events.
This hypothesis is based on the following observations: (1) the beginning of clonal growth is a property strictly dependent on serum and independent of the social context, (2) the expansion of individual clone is influenced by events deriving from a social context during initial growth, (3) clonogenic cells grown in a social context in presence of serum can emancipate themselves to generate a secondary different progeny, and (4) the ability of socially generated clones to develop an inherent potential for further growth suggests that quorum sensing may operate in BM-MSC cultures and determine the potential growth of clonal strains.
American Psychological Association (APA)
Alimandi, Maurizio& Pierelli, Luca& Pino, Valentina& Gentileschi, Stefano& Sacchetti, Benedetto. 2019. The Potential Role of Quorum Sensing in Clonal Growth and Subsequent Expansion of Bone Marrow Stromal Cell Strains in Culture. Stem Cells International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208262
Modern Language Association (MLA)
Alimandi, Maurizio…[et al.]. The Potential Role of Quorum Sensing in Clonal Growth and Subsequent Expansion of Bone Marrow Stromal Cell Strains in Culture. Stem Cells International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1208262
American Medical Association (AMA)
Alimandi, Maurizio& Pierelli, Luca& Pino, Valentina& Gentileschi, Stefano& Sacchetti, Benedetto. The Potential Role of Quorum Sensing in Clonal Growth and Subsequent Expansion of Bone Marrow Stromal Cell Strains in Culture. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208262