Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation
Joint Authors
Pang, Hai-lin
Zhao, Qian-qian
Ma, Yu
Song, Yong-li
Min, Jie
Lu, Jian-rong
Li, Hang
Zhao, Da-qing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-05
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Adipose-derived stem cells (ADSCs) are multipotent and have received increasing attention for their applications in medicine.
Cell-based therapies are optimal for diseases with loss or damage to tissues or organs.
ADSCs and bone marrow mesenchymal stem cells (BMSCs) can differentiate into many cell lineages.
Because of their advantages in accessibility and volume, ADSCs are regarded as a desirable alternative to BMSCs.
In this study, we focused on the chondrocytic differentiation potential of ADSCs and the underlying mechanism.
We found that the long noncoding RNA H19 plays an important role in this process.
Overexpression of H19 in ADSCs induced differentiation towards chondrocytes.
H19 is abundantly expressed during embryonic development and downregulated after birth, implying its regulatory role in determining cell fate.
However, in our experiments, H19 exerted its regulatory function during cartilage differentiation of ADSCs through competing miRNA regulation of STAT2.
American Psychological Association (APA)
Pang, Hai-lin& Zhao, Qian-qian& Ma, Yu& Song, Yong-li& Min, Jie& Lu, Jian-rong…[et al.]. 2019. Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation. Stem Cells International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208351
Modern Language Association (MLA)
Pang, Hai-lin…[et al.]. Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation. Stem Cells International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1208351
American Medical Association (AMA)
Pang, Hai-lin& Zhao, Qian-qian& Ma, Yu& Song, Yong-li& Min, Jie& Lu, Jian-rong…[et al.]. Long Noncoding RNA H19 Participates in the Regulation of Adipose-Derived Stem Cells Cartilage Differentiation. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208351