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The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells
Joint Authors
Qian, Hui
Xu, Wenrong
Zhang, Bin
Shi, Hui
Yang, Lunyu
Rong, Li
You, Benshuai
Wu, Peipei
Han, Xinye
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-12
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Mesenchymal stem cells derived from human umbilical cord (hucMSCs) are considered a promising tool for regenerative medicine.
circRNAs as newly discovered noncoding RNAs are involved in multiple biological processes.
However, little has been known about the function of circRNAs in the proliferation and differentiation of hucMSCs.
In this study, we selected several circRNAs expressed in MSCs from circBase and found that CDR1as expression level was markedly significant.
We observed that, compared with that of uninduced hucMSCs, the CDR1as expression level of induced hucMSCs decreased with cell induction differentiation.
By using siRNA to knock down CDR1as of hucMSCs, we discovered that proliferation was inhibited but the apoptosis increased.
In addition, we found that the expression of stemness transcription factors (STFs) was downregulated after CDR1as knockdown and the adipogenesis and osteogenesis potential of hucMSCs was impaired.
Our findings suggest that CDR1as takes a part in maintaining proliferation and differentiation of hucMSCs, providing clues for MSC modification and further for stem cell therapy and tissue regeneration.
American Psychological Association (APA)
Yang, Lunyu& Zhang, Bin& Shi, Hui& Rong, Li& You, Benshuai& Wu, Peipei…[et al.]. 2019. The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells. Stem Cells International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208413
Modern Language Association (MLA)
Yang, Lunyu…[et al.]. The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells. Stem Cells International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1208413
American Medical Association (AMA)
Yang, Lunyu& Zhang, Bin& Shi, Hui& Rong, Li& You, Benshuai& Wu, Peipei…[et al.]. The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208413