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The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification
Joint Authors
Pei, Luo
Chen, Jie
Xie, Changming
Ouyang, Liu
Zhang, Huanji
Wang, Jingfeng
Huang, Hui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Vascular calcification (VC), characterized by hydroxyapatite crystal depositing in the vessel wall, is a common pathological condition shared by many chronic diseases and an independent risk factor for cardiovascular events.
Recently, VC is regarded as an active, dynamic cell-mediated process, during which calcifying cell transition is critical.
Mesenchymal stem cells (MSCs), with a multidirectional differentiation ability and great potential for clinical application, play a duplex role in the VC process.
MSCs facilitate VC mainly through osteogenic transformation and apoptosis.
Meanwhile, several studies have reported the protective role of MSCs.
Anti-inflammation, blockade of the BMP2 signal, downregulation of the Wnt signal, and antiapoptosis through paracrine signaling are possible mechanisms.
This review displays the evidence both on the facilitating role and on the protective role of MSCs, then discusses the key factors determining this divergence.
American Psychological Association (APA)
Xie, Changming& Ouyang, Liu& Chen, Jie& Zhang, Huanji& Pei, Luo& Wang, Jingfeng…[et al.]. 2019. The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification. Stem Cells International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208574
Modern Language Association (MLA)
Xie, Changming…[et al.]. The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification. Stem Cells International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1208574
American Medical Association (AMA)
Xie, Changming& Ouyang, Liu& Chen, Jie& Zhang, Huanji& Pei, Luo& Wang, Jingfeng…[et al.]. The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1208574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208574