Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods
Joint Authors
Nevi, Lorenzo
Safarikia, Samira
Di Matteo, Sabina
Biancaniello, Francesca
Chiappetta, Michele Francesco
Cardinale, Vincenzo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-01
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Cell adhesion is essential for survival, it plays important roles in physiological cell functions, and it is an innovative target in regenerative medicine.
Among the molecular interactions and the pathways triggered during cell adhesion, the binding of cluster of differentiation 44 (CD44), a cell-surface glycoprotein involved in cell-cell interactions, to hyaluronic acid (HA), a major component of the extracellular matrix, is a crucial step.
Cell therapy has emerged as a promising treatment for advanced liver diseases; however, so far, it has led to low cell engraftment and limited cell repopulation of the target tissue.
Currently, different strategies are under investigation to improve cell grafting in the liver, including the use of organic and inorganic biomatrices that mimic the microenvironment of the extracellular matrix.
Hyaluronans, major components of stem cell niches, are attractive candidates for coating stem cells since they improve viability, proliferation, and engraftment in damaged livers.
In this review, we will discuss the new strategies that have been adopted to improve cell grafting and track cells after transplantation.
American Psychological Association (APA)
Nevi, Lorenzo& Safarikia, Samira& Di Matteo, Sabina& Biancaniello, Francesca& Chiappetta, Michele Francesco& Cardinale, Vincenzo. 2019. Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods. Stem Cells International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1208709
Modern Language Association (MLA)
Nevi, Lorenzo…[et al.]. Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods. Stem Cells International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1208709
American Medical Association (AMA)
Nevi, Lorenzo& Safarikia, Samira& Di Matteo, Sabina& Biancaniello, Francesca& Chiappetta, Michele Francesco& Cardinale, Vincenzo. Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1208709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208709