One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms
Joint Authors
Xu, Xin
Zhou, Xuedong
Zheng, Liwei
Zhou, Yachuan
Wu, Si
Du, Wei
Wan, Mian
Fan, Yi
Zhang, Jun
Li, Feifei
Zhou, Xin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-10
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Beyond energy production, nutrient metabolism plays a crucial role in stem cell lineage determination.
Changes in metabolism based on nutrient availability and dietary habits impact stem cell identity.
Evidence suggests a strong link between metabolism and epigenetic mechanisms occurring during embryonic development and later life of offspring.
Metabolism regulates epigenetic mechanisms such as modifications of DNA, histones, and microRNAs.
In turn, these epigenetic mechanisms regulate metabolic pathways to modify the metabolome.
One-carbon metabolism (OCM) is a crucial metabolic process involving transfer of the methyl groups leading to regulation of multiple cellular activities.
OCM cycles and its related micronutrients are ubiquitously present in stem cells and feed into the epigenetic mechanisms.
In this review, we briefly introduce the OCM process and involved micronutrients and discuss OCM-associated epigenetic modifications, including DNA methylation, histone modification, and microRNAs.
We further consider the underlying OCM-mediated link between nutrition and epigenetic modifications in embryonic development.
American Psychological Association (APA)
Wu, Si& Zhang, Jun& Li, Feifei& Du, Wei& Zhou, Xin& Wan, Mian…[et al.]. 2019. One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms. Stem Cells International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1208756
Modern Language Association (MLA)
Wu, Si…[et al.]. One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms. Stem Cells International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1208756
American Medical Association (AMA)
Wu, Si& Zhang, Jun& Li, Feifei& Du, Wei& Zhou, Xin& Wan, Mian…[et al.]. One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1208756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208756