Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
Joint Authors
Hoffman, Ronald
Papa, Luena
Djedaini, Mansour
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-06
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production.
HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the bone marrow (BM) and reflects the low energetic demands of HSCs.
Metabolic rewiring from glycolysis to mitochondrial-based energy generation accompanies HSC differentiation and lineage commitment.
Recent evidence, however, highlights that alterations in mitochondrial metabolism and activity are not simply passive consequences but active drivers of HSC fate decisions.
Modulation of mitochondrial activity and metabolism is therefore critical for maintaining the self-renewal potential of primitive HSCs and might be beneficial for ex vivo expansion of transplantable HSCs.
In this review, we emphasize recent advances in the emerging role of mitochondria in hematopoiesis, cellular reprograming, and HSC fate decisions.
American Psychological Association (APA)
Papa, Luena& Djedaini, Mansour& Hoffman, Ronald. 2019. Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells. Stem Cells International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208780
Modern Language Association (MLA)
Papa, Luena…[et al.]. Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells. Stem Cells International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1208780
American Medical Association (AMA)
Papa, Luena& Djedaini, Mansour& Hoffman, Ronald. Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1208780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208780