Isolation and Characterization of Neural Stem Cells from the Rat Inferior Colliculus
Joint Authors
Schendzielorz, P.
Rak, K.
Hagen, R.
Völker, Johannes
Engert, Jonas
Völker, Christine
Bieniussa, Linda
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-29
Country of Publication
Egypt
No. of Pages
12
Abstract EN
The inferior colliculus (IC) is a nucleus of the auditory pathway and its fourth relay station.
It integrates afferent information from the superior olivary complex and the cochlear nucleus.
To date, no causal therapeutic options are known for damaged neuronal structures in this area.
Regenerative medicine offers a potential approach to causally treating hearing impairment.
After neural stem cells had been identified in certain areas of the auditory pathway, the question arouses, whether the IC also has a neurogenic potential.
Cells from the IC of postnatal day 6 rats were extracted and cultured as neurospheres.
Cells in the neurospheres showed mitotic activity and positive stain of neural stem cell markers (Nestin, DCX, Atoh1, and Sox-2).
In addition, single cells were differentiated into neuronal and glial cells shown by the markers β-III-tubulin, GFAP, and MBP.
In summary, basic stem cell criteria could be detected and characterized in cells isolated from the IC of the rat.
These findings will lead to a better understanding of the development of the auditory pathway and may also be relevant for identifying causal therapeutic approaches in the future.
American Psychological Association (APA)
Völker, Johannes& Engert, Jonas& Völker, Christine& Bieniussa, Linda& Schendzielorz, P.& Hagen, R.…[et al.]. 2019. Isolation and Characterization of Neural Stem Cells from the Rat Inferior Colliculus. Stem Cells International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1209180
Modern Language Association (MLA)
Völker, Johannes…[et al.]. Isolation and Characterization of Neural Stem Cells from the Rat Inferior Colliculus. Stem Cells International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1209180
American Medical Association (AMA)
Völker, Johannes& Engert, Jonas& Völker, Christine& Bieniussa, Linda& Schendzielorz, P.& Hagen, R.…[et al.]. Isolation and Characterization of Neural Stem Cells from the Rat Inferior Colliculus. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1209180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209180