Autologous Hematopoietic Cell Transplantation in Multiple Sclerosis: Changing Paradigms in the Era of Novel Agents
Joint Authors
Gavriilaki, Eleni
Gavriilaki, Maria
Sakellari, Ioanna
Kimiskidis, Vasilios K.
Anagnostopoulos, Achilles
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-24
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Autologous hematopoietic stem cell transplantation (AHSCT) is established as a standard of care for diseases ranging from hematological malignancies to other neoplastic pathologies and severe immunological deficiencies.
In April 1995, our group performed the first AHSCT in progressive multiple sclerosis (MS).
Since then, a plethora of studies have been published with encouraging but controversial results.
Major challenges in the field include appropriate patient selection, improvements in AHSCT procedure, and timing of this treatment modality.
Beyond AHSCT, several new intravenous or oral agents have been developed and approved over the last 20 years in MS.
The emergence of multiple effective therapies for MS has created a challenging scenario for both treating physicians and patients.
Novel cell-based therapies other than AHSCT are also currently investigated in MS patients with promising results.
Our review is aimed at summarizing state-of-the-art knowledge on basic principles and results of AHSCT in MS and its role compared to novel agents.
American Psychological Association (APA)
Gavriilaki, Maria& Sakellari, Ioanna& Gavriilaki, Eleni& Kimiskidis, Vasilios K.& Anagnostopoulos, Achilles. 2019. Autologous Hematopoietic Cell Transplantation in Multiple Sclerosis: Changing Paradigms in the Era of Novel Agents. Stem Cells International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1209183
Modern Language Association (MLA)
Gavriilaki, Maria…[et al.]. Autologous Hematopoietic Cell Transplantation in Multiple Sclerosis: Changing Paradigms in the Era of Novel Agents. Stem Cells International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1209183
American Medical Association (AMA)
Gavriilaki, Maria& Sakellari, Ioanna& Gavriilaki, Eleni& Kimiskidis, Vasilios K.& Anagnostopoulos, Achilles. Autologous Hematopoietic Cell Transplantation in Multiple Sclerosis: Changing Paradigms in the Era of Novel Agents. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1209183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209183