Is Intragastric Botulinum Toxin A Injection Effective in Obesity Treatment?

Abstract EN

Aims.

The objective of this prospective study was to evaluate the efficacy of intragastric botulinum toxin A (BTX-A) injection for the treatment of obesity.

Materials and Methods.

The study was performed between January and August 2019.

This is a prospective study.

After 6–12 hours of fasting, the patients were submitted to upper GI endoscopy under sedation for the injection of BTX-A.

A total of 250 U of BTA-X was diluted with 10 ml of 0.9% saline.

Injections were administered into the gastric antrum, each containing 1 ml of prepared solution (25 U BX-A + 1 ml saline).

Continuous data were compared using a two-sample t-test.

Statistical significance was determined as P≤0.05.

All statistical analysis was performed using SPSS for Windows 22.1 software (SPSS, Chicago, IL, USA).

Results.

A total of 56 patients were studied.

Mean weight before gastric Botox was 85.25 ± 14.02, and mean weight after gastric Botox was 76.98 ± 12.68.

Mean weight loss was approximately 9 kg in studied patients.

BMI decreased about 3 units.

The mean time for maximum weight loss was 60.39 ± 37.43 days.

A total of 49 patients (87.5%) had reported decrease in appetite and early satiety.

About 53.6% of patients were satisfied.

No complications resulting from the endoscopic procedure were observed in this series.

Conclusions.

Intragastric BTX-A injection can be beneficial in weight loss.

It is a minimally invasive, cost-effective procedure, without serious side effects.