Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit
Joint Authors
Wang, Wei
Qin, Xiao
Wang, Peng
Huang, Yongming
Li, Yansen
Chao, Min
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-22
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Fistula-in-ano (FIA, anal fistula) treatment remains a surgical challenge for coloproctologists.
Adipose tissue-derived stem cells (ADSCs) are a new frontier in the treatment of FIA.
In this study, we established a FIA model of Japanese rabbit and evaluated the effect of four treatments on fistula healing: ADSC transplantation, acellular small intestinal submucosa (ASIS), noncutting seton, and PBS as negative control.
High-throughput RNA sequencing was also performed to investigate the anal tissue (normal and ADSC treatment group) expression profile of mRNA.
Our data showed that ADSC treatment had the shortest time to promote fistula healing compared to the other treatments, and fistula filled with new adipose tissue and muscle cells without scar.
Gene Ontology (GO) analysis of RNA-seq data showed that the differential genes are enriched in system development and animal organ development.
Taken together, our findings demonstrate that ADSCs rapidly promote fistula healing through differentiation, a promising stem cell therapy for FIA.
The rabbit is an effective animal model for evaluating FIA therapeutic options.
American Psychological Association (APA)
Qin, Xiao& Wang, Peng& Huang, Yongming& Li, Yansen& Chao, Min& Wang, Wei. 2019. Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit. Stem Cells International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1209383
Modern Language Association (MLA)
Qin, Xiao…[et al.]. Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit. Stem Cells International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1209383
American Medical Association (AMA)
Qin, Xiao& Wang, Peng& Huang, Yongming& Li, Yansen& Chao, Min& Wang, Wei. Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1209383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209383