Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by Activating Skin Stem Cells via the EGFRMEKERK Pathway
Joint Authors
Minjuan, Wu
Yue, Wang
Song, Jian-Xing
Xiong, Jiachao
Liu, Zhixiao
Ji, Boyao
Wang, Liujun
Yan, Yazhou
Fang, Shuo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Seawater (SW) immersion can increase the damage of skin wounds and produce refractory wounds.
However, few studies have been conducted to investigate the mechanisms of SW immersion on skin wounds.
In our current study, we investigated the effect of human adipose-derived stem cells (hADSCs) on the repair of SW-treated full-thickness skin wounds and the underlying mechanisms.
The results showed that SW immersion could reduce the expression of EGF and suppress the activation of the MEK/ERK signaling pathway.
At the same time, the proliferation and migration of skin stem cells were inhibited by SW immersion, resulting in delayed wound healing.
However, hADSCs significantly accelerated the healing of SW-immersed skin wounds by promoting cell proliferation and migration through the aforementioned mechanisms.
Our results indicate a role for hADSCs in the repair of seawater-immersed skin wounds and suggest a potential novel treatment strategy for seawater-immersed wound healing.
American Psychological Association (APA)
Xiong, Jiachao& Ji, Boyao& Wang, Liujun& Yan, Yazhou& Liu, Zhixiao& Fang, Shuo…[et al.]. 2019. Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by Activating Skin Stem Cells via the EGFRMEKERK Pathway. Stem Cells International،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1209475
Modern Language Association (MLA)
Xiong, Jiachao…[et al.]. Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by Activating Skin Stem Cells via the EGFRMEKERK Pathway. Stem Cells International No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1209475
American Medical Association (AMA)
Xiong, Jiachao& Ji, Boyao& Wang, Liujun& Yan, Yazhou& Liu, Zhixiao& Fang, Shuo…[et al.]. Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by Activating Skin Stem Cells via the EGFRMEKERK Pathway. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1209475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209475