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Intestinal Epithelial Organoids as Tools to Study Epigenetics in Gut Health and Disease
Joint Authors
Kraiczy, Judith
Zilbauer, Matthias
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-27
Country of Publication
Egypt
No. of Pages
7
Abstract EN
The intestinal epithelium forms the inner layer of the human intestine and serves a wide range of diverse functions.
Its constant exposure to a vast amount of complex microbiota highlights the critical interface that this single-cell layer forms between the host and our environment.
Importantly, the well-documented contribution of environmental factors towards the functional development of the human intestinal epithelium directly implies epigenetic mechanisms in orchestrating this complex interplay.
The development of intestinal epithelial organoid culture systems that can be generated from human tissue provides researchers with unpresented opportunities to study functional aspects of human intestinal epithelial pathophysiology.
In this brief review, we summarise existing evidence for the role of epigenetics in regulating intestinal epithelial cell function and highlight the great potential for human gut organoids as translational research tools to investigate these mechanisms in vitro.
American Psychological Association (APA)
Kraiczy, Judith& Zilbauer, Matthias. 2019. Intestinal Epithelial Organoids as Tools to Study Epigenetics in Gut Health and Disease. Stem Cells International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1209504
Modern Language Association (MLA)
Kraiczy, Judith& Zilbauer, Matthias. Intestinal Epithelial Organoids as Tools to Study Epigenetics in Gut Health and Disease. Stem Cells International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1209504
American Medical Association (AMA)
Kraiczy, Judith& Zilbauer, Matthias. Intestinal Epithelial Organoids as Tools to Study Epigenetics in Gut Health and Disease. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1209504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209504