Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming
Joint Authors
Harvey, Alexandra J.
Gardner, David K.
Spyrou, James
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-05
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Reprogramming to pluripotency involves drastic restructuring of both metabolism and the epigenome.
However, induced pluripotent stem cells (iPSC) retain transcriptional memory, epigenetic memory, and metabolic memory from their somatic cells of origin and acquire aberrant characteristics distinct from either other pluripotent cells or parental cells, reflecting incomplete reprogramming.
As a critical link between the microenvironment and regulation of the epigenome, nutrient availability likely plays a significant role in the retention of somatic cell memory by iPSC.
Significantly, relative nutrient availability impacts iPSC reprogramming efficiency, epigenetic regulation and cell fate, and differentially alters their ability to respond to physiological stimuli.
The significance of metabolites during the reprogramming process is central to further elucidating how iPSC retain somatic cell characteristics and optimising culture conditions to generate iPSC with physiological phenotypes to ensure their reliable use in basic research and clinical applications.
This review serves to integrate studies on iPSC reprogramming, memory retention and metabolism, and identifies areas in which current knowledge is limited.
American Psychological Association (APA)
Spyrou, James& Gardner, David K.& Harvey, Alexandra J.. 2019. Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming. Stem Cells International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1209532
Modern Language Association (MLA)
Spyrou, James…[et al.]. Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming. Stem Cells International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1209532
American Medical Association (AMA)
Spyrou, James& Gardner, David K.& Harvey, Alexandra J.. Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1209532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209532