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Environmental Benzopyrene Attenuates Stemness of Placenta-Derived Mesenchymal Stem Cells via Aryl Hydrocarbon Receptor
Joint Authors
Kim, Jin Kwan
Heo, June Seok
Kim, Gi Jin
Lee, Seung Gwan
Lim, Ja-Yun
Pyo, Sangshin
Lee, Dongsook
Ren, Wen Xiu
Yoon, Dae Wui
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-13
Country of Publication
Egypt
No. of Pages
12
Abstract EN
The toxic effects of particulate matter have been linked to polycyclic aromatic hydrocarbons (PAHs) such as benzopyrene.
PAHs are potent inducers of the aryl hydrocarbon receptor (AhR), which is an expressed nuclear receptor that senses environmental stimuli and modulates gene expression.
Even though several studies have shown that the benzopyrene (BP) of chemical pollutants significantly impaired stem cell activity, the exact molecular mechanisms were not clearly elucidated.
In the present study, we aimed to investigate the effects of BP on placenta-derived mesenchymal stem cells (PD-MSCs) in vitro.
We found that the AhR in PD-MSCs was expressed under the treatment of BP, and its activation markedly disrupted osteogenic differentiation through the alteration of stemness activity of PD-MSCs.
Moreover, BP treatment significantly reduced the proliferation activity of PD-MSCs and expression of pluripotent markers through the induction of AhR.
Treatment with StemRegenin 1 (SR1), a purine derivative that antagonizes the AhR, effectively prevented BP-induced reduction of the proliferation and differentiation activity of PD-MSCs.
In this study, we found that BP treatment in PD-MSCs markedly obstructs PD-MSC stemness through AhR signaling.
Noteworthy, SR1-mediated MSC application will contribute to new perspectives on MSC-based therapies for air pollution-related bone diseases.
American Psychological Association (APA)
Heo, June Seok& Lim, Ja-Yun& Pyo, Sangshin& Yoon, Dae Wui& Lee, Dongsook& Ren, Wen Xiu…[et al.]. 2019. Environmental Benzopyrene Attenuates Stemness of Placenta-Derived Mesenchymal Stem Cells via Aryl Hydrocarbon Receptor. Stem Cells International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1209549
Modern Language Association (MLA)
Heo, June Seok…[et al.]. Environmental Benzopyrene Attenuates Stemness of Placenta-Derived Mesenchymal Stem Cells via Aryl Hydrocarbon Receptor. Stem Cells International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1209549
American Medical Association (AMA)
Heo, June Seok& Lim, Ja-Yun& Pyo, Sangshin& Yoon, Dae Wui& Lee, Dongsook& Ren, Wen Xiu…[et al.]. Environmental Benzopyrene Attenuates Stemness of Placenta-Derived Mesenchymal Stem Cells via Aryl Hydrocarbon Receptor. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1209549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209549