Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease
Joint Authors
Müller, Martin
Schulte, L.
Hohwieler, M.
Klaus, J.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-19
Country of Publication
Egypt
No. of Pages
15
Abstract EN
Inflammatory bowel diseases (IBDs) include colitis ulcerosa and Crohn’s disease, besides the rare microscopic colitis.
Both diseases show a long-lasting, relapsing-remitting, or even chronic active course with tremendous impact on quality of life.
IBDs frequently cause disability, surgical interventions, and high costs; as in other autoimmune diseases, their prevalent occurrence at an early phase of life raises the burden on health care systems.
Unfortunately, our understanding of the pathogenesis is still incomplete and treatment therefore largely focuses on suppressing the resulting excessive inflammation.
One obstacle for deciphering the causative processes is the scarcity of models that parallel the development of the disease, since intestinal inflammation is mostly induced artificially; moreover, the intestinal epithelium, which strongly contributes to IBD pathogenesis, is difficult to assess.
Recently, the development of intestinal epithelial organoids has overcome many of those problems.
Here, we give an overview on the current understanding of the pathogenesis of IBDs with reference to the limitations of previous well-established experimental models.
We highlight the advantages and detriments of recent organoid-based experimental setups within the IBD field and suggest possible future applications.
American Psychological Association (APA)
Schulte, L.& Hohwieler, M.& Müller, Martin& Klaus, J.. 2019. Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease. Stem Cells International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1209620
Modern Language Association (MLA)
Schulte, L.…[et al.]. Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease. Stem Cells International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1209620
American Medical Association (AMA)
Schulte, L.& Hohwieler, M.& Müller, Martin& Klaus, J.. Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1209620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209620