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Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder
Joint Authors
Fox, Howard
Moore, Dalia
Meays, Brittney M.
Madduri, Lepakshe S. V.
Shahjin, Farah
Chand, Subhash
Niu, Meng
Albahrani, Abrar
Pendyala, Gurudutt
Yelamanchili, Sowmya V.
Guda, Chittibabu
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
15
Abstract EN
The identification of several evolutionary young miRNAs, which arose in primates, raised several possibilities for the role of such miRNAs in human-specific disease processes.
We previously have identified an evolutionary young miRNA, miR-1290, to be essential in neural stem cell proliferation and neuronal differentiation.
Here, we show that miR-1290 is significantly downregulated during neuronal differentiation in reprogrammed induced pluripotent stem cell- (iPSC-) derived neurons obtained from idiopathic autism spectrum disorder (ASD) patients.
Further, we identified that miR-1290 is actively released into extracellular vesicles.
Supplementing ASD patient-derived neural stem cells (NSCs) with conditioned media from differentiated control-NSCs spiked with “artificial EVs” containing synthetic miR-1290 oligonucleotides significantly rescued differentiation deficits in ASD cell lines.
Based on our earlier published study and the observations from the data presented here, we conclude that miR-1290 regulation could play a critical role during neuronal differentiation in early brain development.
American Psychological Association (APA)
Moore, Dalia& Meays, Brittney M.& Madduri, Lepakshe S. V.& Shahjin, Farah& Chand, Subhash& Niu, Meng…[et al.]. 2019. Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder. Stem Cells International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1209814
Modern Language Association (MLA)
Moore, Dalia…[et al.]. Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder. Stem Cells International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1209814
American Medical Association (AMA)
Moore, Dalia& Meays, Brittney M.& Madduri, Lepakshe S. V.& Shahjin, Farah& Chand, Subhash& Niu, Meng…[et al.]. Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1209814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209814