Dental Follicle Cells: Roles in Development and Beyond
Joint Authors
Xu, Xin
Zhou, Xuedong
Pan, Jinhai
Zheng, Liwei
Wu, Peiyao
Zhou, Yachuan
Wan, Mian
Zhou, Xin
Zhou, Tao
Huang, Ruijie
Du, Wei
Fan, Yi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-15
Country of Publication
Egypt
No. of Pages
17
Abstract EN
Dental follicle cells (DFCs) are a group of mesenchymal progenitor cells surrounding the tooth germ, responsible for cementum, periodontal ligament, and alveolar bone formation in tooth development.
Cascades of signaling pathways and transcriptional factors in DFCs are involved in directing tooth eruption and tooth root morphogenesis.
Substantial researches have been made to decipher multiple aspects of DFCs, including multilineage differentiation, senescence, and immunomodulatory ability.
DFCs were proved to be multipotent progenitors with decent amplification, immunosuppressed and acquisition ability.
They are able to differentiate into osteoblasts/cementoblasts, adipocytes, neuron-like cells, and so forth.
The excellent properties of DFCs facilitated clinical application, as exemplified by bone tissue engineering, tooth root regeneration, and periodontium regeneration.
Except for the oral and maxillofacial regeneration, DFCs were also expected to be applied in other tissues such as spinal cord defects (SCD), cardiomyocyte destruction.
This article reviewed roles of DFCs in tooth development, their properties, and clinical application potentials, thus providing a novel guidance for tissue engineering.
American Psychological Association (APA)
Zhou, Tao& Pan, Jinhai& Wu, Peiyao& Huang, Ruijie& Du, Wei& Zhou, Yachuan…[et al.]. 2019. Dental Follicle Cells: Roles in Development and Beyond. Stem Cells International،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1209922
Modern Language Association (MLA)
Zhou, Tao…[et al.]. Dental Follicle Cells: Roles in Development and Beyond. Stem Cells International No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1209922
American Medical Association (AMA)
Zhou, Tao& Pan, Jinhai& Wu, Peiyao& Huang, Ruijie& Du, Wei& Zhou, Yachuan…[et al.]. Dental Follicle Cells: Roles in Development and Beyond. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1209922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209922