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Postnatal Development of Microglia-Like Cells in Mouse Cochlea
Joint Authors
Yang, Tao
Wu, Hao
Chen, Penghui
Chai, Yongchuan
Liu, Haijin
Li, Gen
Wang, Longhao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Microglial cells are involved in surveillance and cleaning of the central nervous system.
Recently, microglial-like cells (MLC) have been found in an adult cochlea and investigated for their role in cochlear inflammation.
The presence and potential roles of MLCs during the development of the cochlea, however, remain unclear.
In this study, immunostaining was performed using the MLC-specific marker IBA1 to characterize the presence, distribution, and morphology of MLCs in the developing cochlea.
From P0 to P14, MLCs were present in a variety of cochlear regions including the modiolus, spiral lamina, spiral ganglion, spiral ligament, and the organ of Corti.
Interestingly, the overall number of MLCs in a mouse cochlea steadily increased since P0, peaks at P5, then gradually decreased from P5 to P14.
In the spiral ligament, the distribution of the MLCs trends to shift from the type I/II fibrocyte-rich regions to the type III/IV fibrocyte-rich regions during the course of cochlear development, accompanied by the morphological changes of MLCs from the amoeboid, activated form to the ramified, quiescent form.
Our results suggested that MLCs experience drastic morphological and distributional changes during postnatal cochlear development, which may play a role in the maturing and remodeling of the cochlea.
American Psychological Association (APA)
Chen, Penghui& Chai, Yongchuan& Liu, Haijin& Li, Gen& Wang, Longhao& Yang, Tao…[et al.]. 2018. Postnatal Development of Microglia-Like Cells in Mouse Cochlea. Neural Plasticity،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1209974
Modern Language Association (MLA)
Chen, Penghui…[et al.]. Postnatal Development of Microglia-Like Cells in Mouse Cochlea. Neural Plasticity No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1209974
American Medical Association (AMA)
Chen, Penghui& Chai, Yongchuan& Liu, Haijin& Li, Gen& Wang, Longhao& Yang, Tao…[et al.]. Postnatal Development of Microglia-Like Cells in Mouse Cochlea. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1209974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209974