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Transglutaminase 2 Induces Deficits in Social Behavior in Mice
Joint Authors
Crider, Amanda
Davis, Talisha
Ahmed, Anthony O.
Mei, Lin
Pillai, Anilkumar
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Impairments in social behavior are highly implicated in many neuropsychiatric disorders.
Recent studies indicate a role for endoplasmic reticulum (ER) stress in altering social behavior, but the underlying mechanism is not known.
In the present study, we examined the role of transglutaminase 2 (TG2), a calcium-dependent enzyme known to be induced following ER stress, in social behavior in mice.
ER stress induced by tunicamycin administration increased TG2 protein levels in the mouse prefrontal cortex (PFC).
PFC-specific inhibition of TG2 attenuated ER stress-induced deficits in social behavior.
Conversely, overexpression of TG2 in the PFC resulted in social behavior impairments in mice.
In addition, systemic administration of cysteamine, a TG2 inhibitor, attenuated social behavior deficits.
Our preliminary findings using postmortem human brain samples found increases in TG2 mRNA and protein levels in the middle frontal gyrus of subjects with autism spectrum disorder.
These findings in mice and human postmortem brain samples identify changes in TG2 activity in the possible dysregulation of social behavior.
American Psychological Association (APA)
Crider, Amanda& Davis, Talisha& Ahmed, Anthony O.& Mei, Lin& Pillai, Anilkumar. 2018. Transglutaminase 2 Induces Deficits in Social Behavior in Mice. Neural Plasticity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1209975
Modern Language Association (MLA)
Crider, Amanda…[et al.]. Transglutaminase 2 Induces Deficits in Social Behavior in Mice. Neural Plasticity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1209975
American Medical Association (AMA)
Crider, Amanda& Davis, Talisha& Ahmed, Anthony O.& Mei, Lin& Pillai, Anilkumar. Transglutaminase 2 Induces Deficits in Social Behavior in Mice. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1209975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209975