Hollow Mesoporous Silica@Zeolitic Imidazolate Framework Capsules and Their Applications for Gentamicin Delivery
Joint Authors
Chen, Sen
Xu, Kai
Sun, Yu
Kong, Wei-Jia
Xu, Xiaoxiang
Chen, Heyin
Wu, Xia
Qi, Jing
He, Zuhong
Zou, Shengyu
Xie, Le
Yuan, Haitao
Zheng, Haoquan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We have synthesized hollow mesoporous silica (HMS) at a zeolitic imidazolate framework (ZIF) capsule that can be used as a drug delivery system for gentamicin (GM).
The GM is first loaded into HMS.
Then, the outer surface of the GM/HMS is coated with uniformed ZIF nanoparticles (denoted as GM/HMS@ZIF).
The GM/HMS@ZIF has been successfully prepared and acts as a capsule for GM.
The GM/HMS@ZIF shows a good biocompatibility and a good cellular uptake in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells.
The GM is released slowly within 10 h under acidic conditions, which is used to simulate the pH of the endosome and lysosome compartments.
The in vivo assay shows that the signal from fluorescein isothiocyanate (FITC) can be observed after 15 days, when the mice were injected with FITC/HMS@ZIF.
This opens new opportunities to construct a delivery system for GM via one controlled low dose and sustained release for the therapy of Ménière’s disease.
American Psychological Association (APA)
Xu, Xiaoxiang& Chen, Heyin& Wu, Xia& Chen, Sen& Qi, Jing& He, Zuhong…[et al.]. 2018. Hollow Mesoporous Silica@Zeolitic Imidazolate Framework Capsules and Their Applications for Gentamicin Delivery. Neural Plasticity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1209983
Modern Language Association (MLA)
Xu, Xiaoxiang…[et al.]. Hollow Mesoporous Silica@Zeolitic Imidazolate Framework Capsules and Their Applications for Gentamicin Delivery. Neural Plasticity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1209983
American Medical Association (AMA)
Xu, Xiaoxiang& Chen, Heyin& Wu, Xia& Chen, Sen& Qi, Jing& He, Zuhong…[et al.]. Hollow Mesoporous Silica@Zeolitic Imidazolate Framework Capsules and Their Applications for Gentamicin Delivery. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1209983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209983