The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia
Joint Authors
Yao, Dezhong
Luo, Cheng
Lai, Yongxiu
He, Hui
Li, Jianfu
Duan, Mingjun
Chen, Xi
Chang, Xin
Yang, Mi
Liu, Tiejun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Schizophrenia is often associated with behavior abnormality in the cognitive and affective domain.
Music intervention is used as a complementary treatment for improving symptoms in patients with schizophrenia.
However, the neurophysiological correlates of these remissions remain poorly understood.
Here, we investigated the effects of music intervention in neural circuits through functional magnetic resonance imaging (fMRI) study in schizophrenic subjects.
Under the standard care, patients were randomly assigned to music and non-music interventions (MTSZ, UMTSZ) for 1 month.
Resting-state fMRI were acquired over three time points (baseline, 1 month, and 6 months later) in patients and analyzed using functional connectivity strength (FCS) and seed-based functional connection (FC) approaches.
At baseline, compared with healthy controls, decreased FCS in the right middle temporal gyrus (MTG) was observed in patients.
However, after music intervention, the functional circuitry of the right MTG, which was related with the function of emotion and sensorimotor, was improved in MTSZ.
Furthermore, the FC increments were significantly correlated with the improvement of symptoms, while vanishing 6 months later.
Together, these findings provided evidence that music intervention might positively modulate the functional connectivity of MTG in patients with schizophrenia; such changes might be associated with the observed therapeutic effects of music intervention on neurocognitive function.
This trial is registered with ChiCTR-OPC-14005339.
American Psychological Association (APA)
Yang, Mi& He, Hui& Duan, Mingjun& Chen, Xi& Chang, Xin& Lai, Yongxiu…[et al.]. 2018. The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia. Neural Plasticity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210001
Modern Language Association (MLA)
Yang, Mi…[et al.]. The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia. Neural Plasticity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210001
American Medical Association (AMA)
Yang, Mi& He, Hui& Duan, Mingjun& Chen, Xi& Chang, Xin& Lai, Yongxiu…[et al.]. The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210001