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Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome
Joint Authors
Hoymans, Vicky Y.
Vrints, Christiaan J.
Timmermans, Jean-Pierre
Van Laere, Steven J.
Lembrechts, Robrecht
Everaert, Bert R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Background.
Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology.
However, there is still considerable debate about the genotype and function of CAC.
Methods and Results.
Data from publicly available gene expression data sets were used to analyse the transcriptome of in vitro cultured CAC (CACiv).
Genes and pathways of interest were further evaluated using qPCR comparing CACiv versus CD14+ monocytic cells.
The CACiv transcriptome strongly related to tissue macrophages, and more specifically to regulatory M2c macrophages.
The cytokine expression profile of CACiv was predominantly immune modulatory and resembled the cytokine expression of tumor-associated macrophages (TAM).
Pathway analysis revealed previously unrecognized biological processes in CACiv, such as riboflavin metabolism and liver X receptor (LXR)/retinoid X receptor (RXR) and farnesoid X receptor (FXR)/retinoid X receptor (RXR) pathways.
Analysis of endothelial-specific genes did not show evidence for endothelial transdifferentiation.
Conclusions.
CACiv are genotypically similar to regulatory M2c macrophages and lack signs of endothelial differentiation.
American Psychological Association (APA)
Everaert, Bert R.& Van Laere, Steven J.& Lembrechts, Robrecht& Hoymans, Vicky Y.& Timmermans, Jean-Pierre& Vrints, Christiaan J.. 2019. Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome. Stem Cells International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1210012
Modern Language Association (MLA)
Everaert, Bert R.…[et al.]. Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome. Stem Cells International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1210012
American Medical Association (AMA)
Everaert, Bert R.& Van Laere, Steven J.& Lembrechts, Robrecht& Hoymans, Vicky Y.& Timmermans, Jean-Pierre& Vrints, Christiaan J.. Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1210012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210012